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Literature summary for 2.3.2.2 extracted from

  • Keillor, J.W.; Castonguay, R.; Lherbet, C.
    gamma-Glutamyl transpeptidase substrate specificity and catalytic mechanism (2005), Methods Enzymol., 401, 449-467.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Reaction

Reaction Comment Organism Reaction ID
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid the enzyme binds glutathione as donor substrate and initially forms a gamma-glutamyl enzyme that can then react with a water molecule or an acceptor substrate (usually an amino acid or a dipeptide) to form glutamate or a product containing a new gamma-glutamyl isopeptide bond, respectively, thus regenerating the free enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information development of a methods for the indirect evaluation of donor substrate affinity and stereospecificity Homo sapiens ?
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