Application | Comment | Organism |
---|---|---|
pharmacology | cisplatin administration significantly elevates blood urea nitrogen and serum creatinine in male rats day 5 post-treatment. Inhibition of gamma glutamyltranspeptidase prevents cisplatin nephrotoxicity, but not cellular toxicity in rat proximal tubular cultures | Rattus norvegicus |
pharmacology | cisplatin administration significantly elevates blood urea nitrogen and serum creatinine in mice day 4 post-treatment. Inhibition of gamma glutamyltranspeptidase prevents cisplatin nephrotoxicity | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | gamma glutamyltranspeptidase is a key enzyme involved in mediating cisplatin nephrotoxicity, which potentially acts to cleave cisplatin-GSH conjugates to a toxic metabolite | Mus musculus |
physiological function | gamma glutamyltranspeptidase is a key enzyme involved in mediating cisplatin nephrotoxicity, which potentially acts to cleave cisplatin-GSH conjugates to a toxic metabolite | Rattus norvegicus |