Literature summary for 2.3.2.22 extracted from

Bonnefond, L.; Arai, T.; Sakaguchi, Y.; Suzuki, T.; Ishitani, R.; Nureki, O.
Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog (2011), Proc. Natl. Acad. Sci. USA, 108, 3912-3917.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in the apo form and complexed with substrate mimics, at 1.7-2.4 A resolutions. Data show the presence of an aminoacyl-enzyme reaction intermediate, but not a dipeptide tRNA intermediate. Reaction follows a sequential catalytic mechanism, with the successive attachment of two leucine residues on the enzyme via a conserved serine residue	Bacillus licheniformis

Organism

Organism	UniProt	Comment	Textmining
Bacillus licheniformis	Q65EX3	-	-
Bacillus licheniformis ATCC 14580	Q65EX3	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
2 L-leucyl-tRNALeu = 2 tRNALeu + cyclo(L-leucyl-L-leucyl)	sequential catalytic mechanism, with the successive attachment of two leucine residues on the enzyme via a conserved serine residue	Bacillus licheniformis	a

Synonyms

Synonyms	Comment	Organism
YvmC	-	Bacillus licheniformis

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Release 2023.1 (January 2023)