Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | many E2 enzymes are found both in the nucleus and in the cytoplasm. Some E2 enzymes are exclusively restructed to specific compartments | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
35 active E2 enzymes have been identified | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | most E2 enzymes have been identified in a wide variety of tissues and cell types | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
E2 enzyme | - |
Homo sapiens |
ubiquitin-conjugating enzyme (E2) | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the majority of E2s are expressed ubiquitously | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | Some E2s possess N and/or C-terminal extensions that mediate E2-specific processes: class I, enzyme consists of the catalytic domain, without extensions, Class II, enzyme has a N-terminal extension, class III, enzyme has a C-terminal extension, class IV, enzyme has both, N- and C-terminal extensions, showing differences in function, subcellular localization, stabilization of the interaction with E1 enzymes, or modulation of the activity of the interacting E3 | Homo sapiens |
physiological function | the family of ubiquitin-conjugating enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain | Homo sapiens |