Literature summary for 2.3.2.26 extracted from

Yu, J.; Lan, J.; Zhu, Y.; Li, X.; Lai, X.; Xue, Y.; Jin, C.; Huang, H.
The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara (2008), Biochem. Biophys. Res. Commun., 367, 805-812.

Search for more literature for 2.3.2.26

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q5T447	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[ubiquitin ligase HECTD3]-S-ubiquitin-L-cysteine + [Tara]-L-lysine	Tara, Trio-associated repeat on actin, is an interacting partner of guanine nucleotide exchange factors Trio and TRF1. Ubiquitin-protein ligase HECTD3 directly binds Tara in vitro and forms a complex with Tara in vivo. Overexpression of HECTD3 enhances the ubiquitination of Tara in vivo and promotes the turnover of Tara, whereas depletion of HECTD3 by small interfering RNA decreases Tara degradation	Homo sapiens	[ubiquitin ligase HECTD3]-L-cysteine + [Tara]-N6-ubiquitinyl-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
HECTD3	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	depletion of ubiquitin-protein ligase HECTD3 leads to multipolar spindle formation	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)