Literature summary for 2.3.2.26 extracted from

Li, Y.; Ozaki, T.; Kikuchi, H.; Yamamoto, H.; Ohira, M.; Nakagawara, A.
A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner (2008), Oncogene, 27, 3700-3709.

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Application

Application	Comment	Organism
medicine	functional interaction of NEDD4-like ubiquitin protein ligase NEDL1 with p53 might contribute to the induction of apoptosis in cancerous cells bearing wild-type p53	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q76N89	-	-

Synonyms

Synonyms	Comment	Organism
NEDL1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	NEDD4-like ubiquitin protein ligase NEDL1 cooperates with p53 to induce apoptosis. During cisplatin -mediated apoptosis in neuroblastoma SH-SY5Y cells, p53 is induced to accumulate in association with an increase in expression levels of NEDL1. Enforced expression of NEDL1 results in a decrease in number of G418-resistant colonies in SH-SY5Y and U2OS cells bearing wild-type p53, whereas NEDL1 had undetectable effect on p53-deficient H1299 and SAOS-2 cells. Enforced expression of NEDL1 increases the number of U2OS cells with sub-G1 DNA content. NEDL1 binds to the COOH-terminal region of p53 and has an ability to enhance the transcriptional activity of p53. Small interfering RNA-mediated knockdown of the endogenous NEDL1 confers the resistance of U2OS cells to adriamycin. NEDL1 enhances pro-apoptotic activity of p53 in its catalytic activity-independent manner	Homo sapiens

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Release 2023.1 (January 2023)