Protein Variants | Comment | Organism |
---|---|---|
medicine | isoform HECTD3 is frequently overexpressed in breast carcinomas suggesting that caspase-8 ubiquitination by HECTD3 confers cancer cell survival | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q5T447 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [caspase-8]-L-lysine | - |
Homo sapiens | [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[caspase-8]-L-lysine | isoform HECTD3 ubiquitinates caspase-8 with K63-linked polyubiquitin chains that do not target caspase-8 for degradation but decrease the caspase-8 activation | ? |
Synonyms | Comment | Organism |
---|---|---|
HECTD3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | HECTD3 depletion can sensitize cancer cells to extrinsic apoptotic stimuli. HECTD3 inhibits TNF-related apoptosis-inducing ligand-induced caspase-8 cleavage in an E3 ligase activity-dependent manner. Mutation of the caspase-8 ubiquitination site at K215 abolishes the HECTD3 protection from TNF-related apoptosis-inducing ligand-induced cleavage | Homo sapiens |