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Literature summary for 2.3.2.27 extracted from

  • Brophy, T.M.; Raab, M.; Daxecker, H.; Culligan, K.G.; Lehmann, I.; Chubb, A.J.; Treumann, A.; Moran, N.
    RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3 (2008), Biochem. Biophys. Res. Commun., 369, 1088-1093.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ ubiquitination in the platelet is modulated by elevated intracellular calcium level Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9P0P0 isoform RN181
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform RN181 interacts with the KVGFFKR region of platelet integrin alphaIIbbeta3. The integrin is not an endogenous substrate for RN181-directed ubiquitination Homo sapiens ?
-
?
[RN181-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [RN181]-L-lysine
-
Homo sapiens [RN181-ubiquitin-carrier protein]-L-cysteine + [RN181]-N6-ubiquitinyl-L-lysine in the presence of a ubiquitin-activating E1 enzyme, a ubiquitin-conjugating E2 enzyme, ubiquitin monomers and ATP, RN181 is self-ubiquitinated ?

Subunits

Subunits Comment Organism
More isoform RN181 interacts with the KVGFFKR region of platelet integrin alphaIIbbeta3. The integrin is not an endogenous substrate for RN181-directed ubiquitination Homo sapiens

Synonyms

Synonyms Comment Organism
HSPC238
-
Homo sapiens
RN181
-
Homo sapiens