Literature summary for 2.3.2.27 extracted from

Duan, Z.; Gao, B.; Xu, W.; Xiong, S.
Identification of TRIM22 as a RING finger E3 ubiquitin ligase (2008), Biochem. Biophys. Res. Commun., 374, 502-506.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS-7 cell and 293-T cell	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8IYM9	isoform TRIM22	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[TRIM22-ubiquitin-carrier protein UbcH5B]-S-ubiquitinyl-L-cysteine + [TRIM22]-L-lysine	-	Homo sapiens	[TRIM22-ubiquitin-carrier protein UbcH5B]-L-cysteine + [TRIM22]-N6-ubiquitinyl-L-lysine	isoform undergoes self-ubiquitylation in vitro in combination with the E2 enzyme UbcH5B, the ubiquitylation is dependent on its RING finger domain. TRIM22 is conjugated with poly-ubiquitin chains and stabilized by proteasome inhibitor in 293T cells	?

Synonyms

Synonyms	Comment	Organism
TRIM22	-	Homo sapiens

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Release 2023.1 (January 2023)