Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96PM5 | isoform PirH2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[PirH2-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [PolH]-L-lysine | PolH, DNA polymerase eta, a Y family translesion polymerase and a target of the p53 tumor suppressor. PolH interacts with Pirh2 E3 ligase, via the polymerase-associated domain in PolH and the RING finger domain in Pirh2. PolH is recruited by Pirh2 and degraded by 20S proteasome in a ubiquitin-independent manner | Homo sapiens | [PirH2-ubiquitin-carrier protein]-L-cysteine + [PolH]-N6-ubiquitinyl-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Pirh2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of E3 ligase Pirh2 decreases DNA polymerase PolH protein stability, whereas knockdown of Pirh2 increases it. Pirh2 knockdown leads to accumulation of PolH and, subsequently, enhances the survival of UV-irradiated cells | Homo sapiens |