Crystallization (Comment) | Organism |
---|---|
solution structure of the isoform HHARI RING2 domain, the key portion of this E3 ligase required for the RING/HECT hybrid mechanism. The domain possesses two Zn2+-binding sites and a single exposed cysteine used for ubiquitin catalysis. A structural comparison of the RING2 domain with the HECT E3 ligase NEDD4 reveals a near mirror image of the cysteine and histidine residues in the catalytic site. A tandem pair of aromatic residues exists near the C-terminus of the HHARI RING2 domain that is conserved in other RING-in-Between-RING E3 ligases | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | two Zn2+-binding sites are present involving four cysteine residues found in the loops between beta1-beta2 and beta3-beta4 at site I, residues C344, C347, C362, C367, and three cysteines and a histidine in the extended loop after beta4 at site II, residues C372, C375, H382, C389 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y4X5 | isoform HHARI | - |
Synonyms | Comment | Organism |
---|---|---|
ARIH1 | - |
Homo sapiens |
HHARI | - |
Homo sapiens |
Human Homologue of Drosophila Ariadne | - |
Homo sapiens |