Literature summary for 2.3.2.27 extracted from

Wang, Y.; Kim, S.M.; Trnka, M.J.; Liu, Y.; Burlingame, A.L.; Correia, M.A.
Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes (2015), J. Biol. Chem., 290, 3308-3332.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UKV5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ubiquitinyl-[Ubc7]-L-cysteine + [CYP3A4]-L-lysine	-	Homo sapiens	[Ubc7]-L-cysteine + N6-ubiquitinyl-[CYP3A4]-L-lysine	human liver endoplasmic reticulum-anchored cytochrome P450 enzyme CYP3A4 is degradedvia ubiquitylation by E2 ubiquitin-conjugating enzyme Ubc7/E3 ubiquitin-ligase gp78. CYP3A4 Asp/Glu/Ser(P)/Thr(P) surface clusters are important for its intermolecular electrostatic interactions with each of these E2-E3 subcomponents. By imparting additional negative charge to these Asp/Glu clusters, such Ser/Thr phosphorylation would generate P450 phosphodegrons for molecular recognition by the E2-E3 complexes, thereby controlling the timing of CYP3A4 ubiquitination and endoplasmic reticulum-associated degradation	?

Synonyms

Synonyms	Comment	Organism
AMFR	-	Homo sapiens
gp78	-	Homo sapiens

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Release 2023.1 (January 2023)