Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | inactivated enzyme can be fully restored by addition of Zn2+ in the presence of equimolar concentrations of EDTA, little reactivation by Co2+ and Mn2+ | Homo sapiens | |
1,4-bis-(imidazol-1-yl)methyl-2,5-dimethylbenzene | - |
Homo sapiens | |
1-(2-oxo-2-phenylethyl)-imidazole | - |
Homo sapiens | |
1-(3-aminopropyl)-imidazole | - |
Homo sapiens | |
1-(6-phenoxyhexyl)-1H-imidazole | - |
Homo sapiens | |
1-Benzylimidazole | - |
Homo sapiens | |
1-methyl-4-(beta-aminoethyl)-imidazole | - |
Homo sapiens | |
1-methyl-5-(beta-aminoethyl)-imidazole | - |
Homo sapiens | |
1-Methylimidazole | - |
Homo sapiens | |
1-vinylimidazole | - |
Homo sapiens | |
2-aminobenzimidazole | - |
Homo sapiens | |
2-ethyl-4-methyl-imidazole | - |
Homo sapiens | |
2-methyl-benzylimidazole | - |
Homo sapiens | |
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one | - |
Homo sapiens | |
4-(2-imidazol-1-yl-ethoxy)-benzoic acid | - |
Homo sapiens | |
4-imidazole-carboxaldehyde | - |
Homo sapiens | |
5-amino-3H-imidazole-4-carboxylic acid amide | - |
Homo sapiens | |
5-hydroxymethyl-4-methyl-imidazole | - |
Homo sapiens | |
benzimidazole | - |
Homo sapiens | |
dipicolinic acid | inactivated enzyme can be fully restored by addition of Zn2+ in the presence of equimolar concentrations of EDTA, little reactivation by Co2+ and Mn2+ | Homo sapiens | |
H-His-Trp-OH | - |
Homo sapiens | |
imidazol-4-carbonic acid methylester | - |
Homo sapiens | |
imidazole | - |
Homo sapiens | |
L-histamine | - |
Homo sapiens | |
L-histidinamide | - |
Homo sapiens | |
L-histidine | - |
Homo sapiens | |
L-histidinol | - |
Homo sapiens | |
N-(4-chlorophenyl)-N'-[2-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one | - |
Homo sapiens | |
N-(trimethylsilyl)-imidazole | - |
Homo sapiens | |
N-Acetylimidazole | - |
Homo sapiens | |
N-benzoylimidazole | - |
Homo sapiens | |
N-omega-acetylhistamine | - |
Homo sapiens | |
oxalic acid diimidazolidide | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be restored partially by Co2+ or Mn2+ | Homo sapiens | |
Mn2+ | enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be restored partially by Co2+ or Mn2+ | Homo sapiens | |
Zn2+ | enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be fully restored by addition of Zn2+ in the presence of equimolar concentrations of EDTA | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16769 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gln-7-amido-4-methylcoumarin | - |
Homo sapiens | pyroglutamic acid-7-amido-4-methylcoumarin + NH3 | - |
? | |
Gln-Gln | - |
Homo sapiens | pyroglutamic acid-Gln + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutaminyl cyclase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
N-(4-chlorophenyl)-N'-[2-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one | 30°C, pH 8.0 | Homo sapiens | |
0.0023 | - |
4-(2-imidazol-1-yl-ethoxy)-benzoic acid | 30°C, pH 8.0 | Homo sapiens | |
0.0062 | - |
1-(6-phenoxyhexyl)-1H-imidazole | - |
Homo sapiens | |
0.0071 | - |
1-Benzylimidazole | 30°C, pH 8.0 | Homo sapiens | |
0.017 | - |
N-omega-acetylhistamine | 30°C, pH 8.0 | Homo sapiens | |
0.03 | - |
1-Methylimidazole | 30°C, pH 8.0 | Homo sapiens | |
0.049 | - |
1-vinylimidazole | 30°C, pH 8.0 | Homo sapiens | |
0.078 | - |
oxalic acid diimidazolidide | 30°C, pH 8.0 | Homo sapiens | |
0.103 | - |
imidazole | 30°C, pH 8.0 | Homo sapiens | |
0.107 | - |
N-Acetylimidazole | 30°C, pH 8.0 | Homo sapiens | |
0.12 | - |
1-methyl-5-(beta-aminoethyl)-imidazole | 30°C, pH 8.0 | Homo sapiens | |
0.129 | - |
5-hydroxymethyl-4-methyl-imidazole | 30°C, pH 8.0 | Homo sapiens | |
0.138 | - |
benzimidazole | 30°C, pH 8.0 | Homo sapiens | |
0.165 | - |
2-methyl-benzylimidazole | 30°C, pH 8.0 | Homo sapiens | |
0.167 | - |
N-(trimethylsilyl)-imidazole | 30°C, pH 8.0 | Homo sapiens | |
0.174 | - |
N-benzoylimidazole | 30°C, pH 8.0 | Homo sapiens | |
0.184 | - |
1-(2-oxo-2-phenylethyl)-imidazole | 30°C, pH 8.0 | Homo sapiens | |
0.295 | - |
1,4-bis-(imidazol-1-yl)methyl-2,5-dimethylbenzene | 30°C, pH 8.0 | Homo sapiens | |
0.41 | - |
1-(3-aminopropyl)-imidazole | 30°C, pH 8.0 | Homo sapiens | |
0.56 | - |
L-histidinamide | 30°C, pH 8.0 | Homo sapiens | |
0.58 | - |
2-ethyl-4-methyl-imidazole | 30°C, pH 8.0 | Homo sapiens | |
0.6 | - |
H-His-Trp-OH | 30°C, pH 8.0 | Homo sapiens | |
0.818 | - |
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one | 30°C, pH 8.0 | Homo sapiens | |
0.85 | - |
L-histamine | 30°C, pH 8.0 | Homo sapiens | |
1.53 | - |
L-histidinol | 30°C, pH 8.0 | Homo sapiens | |
1.8 | - |
2-aminobenzimidazole | 30°C, pH 8.0 | Homo sapiens | |
4.4 | - |
L-histidine | 30°C, pH 8.0 | Homo sapiens | |
7.6 | - |
4-imidazole-carboxaldehyde | 30°C, pH 8.0 | Homo sapiens | |
14.5 | - |
imidazol-4-carbonic acid methylester | 30°C, pH 8.0 | Homo sapiens | |
15.5 | - |
5-amino-3H-imidazole-4-carboxylic acid amide | 30°C, pH 8.0 | Homo sapiens |