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Literature summary for 2.3.2.5 extracted from

  • Buchholz, M.; Heiser, U.; Schilling, S.; Niestroj, A.J.; Zunkel, K.; Demuth, H.U.
    The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship (2006), J. Med. Chem., 49, 664-677.
    View publication on PubMed
Search for more literature for 2.3.2.5

Inhibitors

Inhibitors Comment Organism Structure
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
1-(2,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
1-(3,4-dimethoxybenzyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-(2-[1-(1H-imidazol-1-yl)cyclopropyl]ethyl)thiourea
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-[(3R)-3-(1H-imidazol-1-yl)butyl]thiourea
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-[(3S)-3-(1H-imidazol-1-yl)butyl]thiourea
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]urea
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-[4-(1H-imidazol-1-yl)butyl]thiourea
-
 Homo sapiens
1-(3,5-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
1-(4-acetylphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
1-(4-ethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
1-(4-ethylphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
1-[3-(1H-imidazol-1-yl)propyl]-3-(1-naphthyl)thiourea
-
 Homo sapiens
1-[3-(1H-imidazol-1-yl)propyl]-3-(3,4,5-trimethoxyphenyl)thiourea
-
 Homo sapiens
1-[3-(1H-imidazol-1-yl)propyl]-3-(3-methoxyphenyl)thiourea
-
 Homo sapiens
1-[3-(1H-imidazol-1-yl)propyl]-3-(4-methoxyphenyl)thiourea
-
 Homo sapiens
1-[3-(1H-imidazol-1-yl)propyl]-3-(4-methylphenyl)thiourea
-
 Homo sapiens
1-[3-(1H-imidazol-1-yl)propyl]-3-[4-(methylthio)phenyl]thiourea
-
 Homo sapiens
1-[4-(benzyloxy)phenyl]-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
 Homo sapiens
N-[3-(1H-imidazol-1-yl)propyl]-5-methoxy-1,3-benzothiazol-2-amine
-
 Homo sapiens
N-[3-(1H-imidazol-1-yl)propyl]-6-methoxy-1,3-benzothiazol-2-amine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Gln-7-amido-4-methylcoumarin
-
 Homo sapiens pyroglutamate-7-amido-4-methylcoumarin + NH3
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00006
-
 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens
0.00034
-
 1-[3-(1H-imidazol-1-yl)propyl]-3-(3,4,5-trimethoxyphenyl)thiourea pH 8.0, 30°C Homo sapiens
0.00034
-
 1-(3,4-dimethoxyphenyl)-3-[(3R)-3-(1H-imidazol-1-yl)butyl]thiourea pH 8.0, 30°C Homo sapiens
0.00049
-
 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]urea pH 8.0, 30°C Homo sapiens
0.00055
-
 1-(3,4-dimethoxyphenyl)-3-[4-(1H-imidazol-1-yl)butyl]thiourea pH 8.0, 30°C Homo sapiens
0.00056
-
 1-(2,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens
0.0007
-
 1-[3-(1H-imidazol-1-yl)propyl]-3-(4-methoxyphenyl)thiourea pH 8.0, 30°C Homo sapiens
0.00075
-
 1-(3,5-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens
0.00076
-
 1-(3,4-dimethoxyphenyl)-3-[(3S)-3-(1H-imidazol-1-yl)butyl]thiourea pH 8.0, 30°C Homo sapiens
0.00089
-
 1-(4-ethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens
0.00097
-
 1-[4-(benzyloxy)phenyl]-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens
0.00112
-
 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens
0.00155
-
 1-(3,4-dimethoxybenzyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens
0.00157
-
 N-[3-(1H-imidazol-1-yl)propyl]-6-methoxy-1,3-benzothiazol-2-amine pH 8.0, 30°C Homo sapiens
0.00166
-
 1-[3-(1H-imidazol-1-yl)propyl]-3-[4-(methylthio)phenyl]thiourea pH 8.0, 30°C Homo sapiens
0.0018
-
 1-(4-acetylphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens
0.00186
-
 1-[3-(1H-imidazol-1-yl)propyl]-3-(3-methoxyphenyl)thiourea pH 8.0, 30°C Homo sapiens
0.002
-
 N-[3-(1H-imidazol-1-yl)propyl]-5-methoxy-1,3-benzothiazol-2-amine pH 8.0, 30°C Homo sapiens
0.00214
-
 1-[3-(1H-imidazol-1-yl)propyl]-3-(4-methylphenyl)thiourea pH 8.0, 30°C Homo sapiens
0.00233
-
 1-(3,4-dimethoxyphenyl)-3-(2-[1-(1H-imidazol-1-yl)cyclopropyl]ethyl)thiourea pH 8.0, 30°C Homo sapiens
0.0028
-
 1-[3-(1H-imidazol-1-yl)propyl]-3-(1-naphthyl)thiourea pH 8.0, 30°C Homo sapiens
0.0028
-
 1-(4-ethylphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea pH 8.0, 30°C Homo sapiens