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Literature summary for 2.3.2.B1 extracted from

  • Cressina, E.; Lloyd, A.J.; De Pascale, G.; Mok, B.J.; Caddick, S.; Roper, D.I.; Dowson, C.G.; Bugg, T.D.H.
    Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors (2009), Bioorg. Med. Chem., 17, 3443-3455.
    View publication on PubMed
Search for more literature for 2.3.2.B1

Inhibitors

Inhibitors Comment Organism Structure
2'-(1-amino ethyl phosphonyl) adenosine 1 mM, 55% inhibition Streptococcus pneumoniae
3'-(1-amino ethyl phosphonyl) 2'-deoxyadenosine 1 mM, 95% inhibition Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ditrans,ocatacis-undecaprenyl diphosphoryl (GlcNAc-beta-(1->4))MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-Ala-tRNa
-
 Streptococcus pneumoniae ditrans,ocatacis-undecaprenyl diphosphoryl (GlcNAc-beta-(1->4))MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl(N6-L-alanyl)-D-alanyl-D-alanine + tRNA
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.1
-
 pH 6.8, 37°C Streptococcus pneumoniae 3'-(1-amino ethyl phosphonyl) 2'-deoxyadenosine
0.78
-
 pH 6.8, 37°C Streptococcus pneumoniae 2'-(1-amino ethyl phosphonyl) adenosine