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Literature summary for 2.3.2.B12 extracted from

  • Metzger, M.B.; Weissman, A.M.;
    Working on a chain: E3s ganging up for ubiquitylation (2010), Nat. Cell Biol., 12, 1124-1126.
    View publication on PubMed
Search for more literature for 2.3.2.B12

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
-

Reaction

Reaction Comment Organism Reaction ID
S-ubiquitinyl-[U-box-E4-ubiquitin-carrier protein]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine = [U-box-E4-ubiquitin-carrier protein]-L-cysteine + N6-(N6-ubiquitinyl-L-lysyl)-ubiquitinyl-[acceptor protein]-L-lysine E4 used to describe an E3 when it enhances ubiquitin chain elongation and potentialy also forms additional chains Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Ufd4-enhancing ubiquitinylation of N-end rule substrates, Lys48 ubiquitin-chain formation and proteasomal degradation Saccharomyces cerevisiae ?
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 ?

Synonyms

Synonyms Comment Organism
E4
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 Saccharomyces cerevisiae
Ubr1-dependent E4 enzyme
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 Saccharomyces cerevisiae
Ufd4
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 Saccharomyces cerevisiae
Ufd4-enhancing ubiquitiylation enzyme
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function E4 is an additional factor working together with ubiquitin-activating enzyme E1, ubiquitin-conjugating enzyme E2, and ubiquitin transferase E3, in some cases specifically required for multiubiquitin chain polymerization, a function attributed to Ufd2, the first protein designated as an E4 Saccharomyces cerevisiae