Literature summary for 2.3.2.B12 extracted from

Woodfield, S.E.; Guo, R.J.; Liu, Y.; Major, A.M.; Hollingsworth, E.F.; Indiviglio, S.; Whittle, S.B.; Mo, Q.; Bean, A.J.; Ittmann, M.; Lopez-Terrada, D.; Zage, P.E.
Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B (2016), Genes Cancer, 7, 13-26 .

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Application

Application	Comment	Organism
medicine	low UBE4B gene expression is associated with poor outcomes in patients with neuroblastoma and with worse outcomes in all patient subgroups. UBE4B protein expression is associated with neuroblastoma tumor differentiation, and decreased UBE4B protein levels are associated with high-risk features. UBE4B protein levels are also associated with levels of phosphorylated ERK	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O95155	isoform UBE4B, cf. EC 2.3.2.27	-

Synonyms

Synonyms	Comment	Organism
UBE4B	-	Homo sapiens

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Release 2023.1 (January 2023)