Literature summary for 2.3.2.B12 extracted from

Liu, C.; Liu, W.; Ye, Y.; Li, W.
Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains (2017), Nat. Commun., 8, 14274 .

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P54860	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ubiquitinyl-[U-box-E4-ubiquitin-carrier protein]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine	-	Saccharomyces cerevisiae	[U-box-E4-ubiquitin-carrier protein]-L-cysteine + N6-[N6-ubiquitinyl-L-lysyl]-ubiquitinyl-[acceptor protein]-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
Ufd2	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	Ufd2 catalyses K48-linked multi-monoubiquitination on K29-linked ubiquitin chains assembled by the ubiquitin ligase Ufd4, resulting in branched ubiquitin chains. The reaction depends on the interaction of K29-linked ubiquitin chains with two N-terminal loops of Ufd2. Only following the addition of K48-linked ubiquitin to substrates modified with K29-linked ubiquitin chains, the substrates can be escorted to the proteasome for degradation. This ubiquitin chain linkage switching reaction is essential for ERAD, oleic acid and acid pH resistance in yeast	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)