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Literature summary for 2.3.2.B8 extracted from

  • Schumacher, F.R.; Wilson, G.; Day, C.L.
    The N-terminal extension of UBE2E ubiquitin-conjugating enzymes limits chain assembly (2013), J. Mol. Biol., 425, 4099-4111.
    View publication on PubMed
Search for more literature for 2.3.2.B8

Protein Variants

Protein Variants Comment Organism
S68A the mutant shows wild type activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21400
-
 1 * 21400, calculated from amino acid sequence Homo sapiens
22400
-
 1 * 22400, SEC-MALS analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine + [HECT-E3-ubiquitin-carrier protein]-L-cysteine Homo sapiens
-
 [ubiquitin-carrier protein E2]-L-cysteine + S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein]-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the full-length UBE2E proteins primarily promote protein monoubiquitylation, whereas the core UBC domain of each can efficiently build polyubiquitin chains Homo sapiens ?
-
 ?
S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine + [HECT-E3-ubiquitin-carrier protein cIAP2]-L-cysteine
-
 Homo sapiens [ubiquitin-carrier protein E2]-L-cysteine + S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein cIAP2]-L-cysteine
-
 ?
S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine + [HECT-E3-ubiquitin-carrier protein]-L-cysteine
-
 Homo sapiens [ubiquitin-carrier protein E2]-L-cysteine + S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein]-L-cysteine
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 21400, calculated from amino acid sequence Homo sapiens
monomer 1 * 22400, SEC-MALS analysis Homo sapiens

Synonyms

Synonyms Comment Organism
UbcH6
-
 Homo sapiens
UBE2E1
-
 Homo sapiens