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Literature summary for 2.3.3.13 extracted from

  • Singh, K.; Bhakuni, V.
    Cation induced differential effect on structural and functional properties of Mycobacterium tuberculosis alpha -isopropylmalate synthase (2007), BMC Struct. Biol., 7, 39.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ the ion interacts directly with the catalytic domain of the enzyme and induce unfolding/denaturation of the domain Mycobacterium tuberculosis
Zn2+ the ion interacts directly with the catalytic domain of the enzyme and induce unfolding/denaturation of the domain Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
K+ the activator interacts with the catalytic TIM barrel domain, it does not induce any significant effect on the enzyme structure Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Synonyms

Synonyms Comment Organism
Alpha-isopropylmalate synthase
-
Mycobacterium tuberculosis
MtalphaIPMS
-
Mycobacterium tuberculosis