Literature summary for 2.3.3.14 extracted from

Gray, G.S.; Bhattacharjee, J.K.
Biosynthesis of lysine in Saccharomyces cerevisiae: Regulation of homocitrate synthase in analogue-resistant mutants (1976), J. Gen. Microbiol., 97, 117-120.

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Inhibitors

Inhibitors	Comment	Organism	Structure
hydroxylysine	DL-hydroxylysine	Saccharomyces cerevisiae
L-Arg	-	Saccharomyces cerevisiae
L-norleucine	-	Saccharomyces cerevisiae
thialysine	5 mM, complete inhibition	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + H2O + 2-oxoglutarate	Saccharomyces cerevisiae	first enzyme of the 2-aminoadipic acid pathway for biosynthesis of lysine	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + H2O + 2-oxoglutarate	-	Saccharomyces cerevisiae	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?
acetyl-CoA + H2O + 2-oxoglutarate	first enzyme of the 2-aminoadipic acid pathway for biosynthesis of lysine	Saccharomyces cerevisiae	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

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Release 2023.1 (January 2023)