Literature summary for 2.3.3.14 extracted from

Banuelos, O.; Casqueiro, J.; Fierro, F.; Hijarrubia, M.J.; Gutierrez, S.; Matin, J.F.
Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase (1999), Gene, 226, 51-59.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + H2O + 2-oxoglutarate	Penicillium chrysogenum	expression of lys1 is partially repressed by high concentrations of lysine in the culture medium, but lysine repression seems to be a weak mechanism of control of the lysine pathway as compared to lysine inhibition of homocitrate synthase	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Penicillium chrysogenum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + H2O + 2-oxoglutarate	-	Penicillium chrysogenum	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?
acetyl-CoA + H2O + 2-oxoglutarate	expression of lys1 is partially repressed by high concentrations of lysine in the culture medium, but lysine repression seems to be a weak mechanism of control of the lysine pathway as compared to lysine inhibition of homocitrate synthase	Penicillium chrysogenum	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

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Release 2023.1 (January 2023)