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Literature summary for 2.3.3.14 extracted from

  • Qian, J.; West, A.H.; Cook, P.F.
    Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae (2006), Biochemistry, 45, 12136-12143.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate
-
Saccharomyces cerevisiae
2-Oxomalonate
-
Saccharomyces cerevisiae
Glutarate
-
Saccharomyces cerevisiae
glyoxylate competitive, analysis of pH-dependence of inhibition Saccharomyces cerevisiae
oxalate
-
Saccharomyces cerevisiae
oxaloacetate
-
Saccharomyces cerevisiae
oxalylglycine
-
Saccharomyces cerevisiae
pyridine-2,3-dicarboxylate
-
Saccharomyces cerevisiae
Pyridine-2,4-dicarboxylate
-
Saccharomyces cerevisiae
Pyridine-2,5-dicarboxylate
-
Saccharomyces cerevisiae
pyridine-2,6-dicarboxylate
-
Saccharomyces cerevisiae
pyridine-2-carboxylate
-
Saccharomyces cerevisiae
succinyl phosphonate
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc bound in the active site Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA mechanism: 2-oxoglutarate first binds to the active site zinc via its alpha-carboxylate and 2-oxo groups, followed by acetyl-CoA. A general base then accepts a proton from the methyl of acetyl-CoA, and a general acid protonates the carbonyl of 2-oxoglutarate in the formation of homocitryl-CoA. The general acid then acts as a base in deprotonating Zn-OH2 in the hydrolysis of homocitryl-CoA to give homocitrate and CoA Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.4
-
glyoxylate pH 7.2 Saccharomyces cerevisiae
0.43
-
pyridine-2-carboxylate pH 7.2 Saccharomyces cerevisiae
0.6
-
Pyridine-2,4-dicarboxylate pH 7.2 Saccharomyces cerevisiae
0.7
-
pyridine-2,6-dicarboxylate pH 7.2 Saccharomyces cerevisiae
1
-
oxalate pH 7.2 Saccharomyces cerevisiae
3
-
pyridine-2,3-dicarboxylate pH 7.2 Saccharomyces cerevisiae
4
-
oxaloacetate pH 7.2 Saccharomyces cerevisiae
7.7
-
oxalylglycine pH 7.2 Saccharomyces cerevisiae
10
-
2-Oxomalonate pH 7.2 Saccharomyces cerevisiae
14
-
Pyridine-2,5-dicarboxylate pH 7.2 Saccharomyces cerevisiae
26
-
2-oxoglutarate pH 7.2 Saccharomyces cerevisiae
26
-
Glutarate pH 7.2 Saccharomyces cerevisiae
46
-
succinyl phosphonate pH 7.2 Saccharomyces cerevisiae