Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | - |
Saccharomyces cerevisiae | |
2-Oxomalonate | - |
Saccharomyces cerevisiae | |
Glutarate | - |
Saccharomyces cerevisiae | |
glyoxylate | competitive, analysis of pH-dependence of inhibition | Saccharomyces cerevisiae | |
oxalate | - |
Saccharomyces cerevisiae | |
oxaloacetate | - |
Saccharomyces cerevisiae | |
oxalylglycine | - |
Saccharomyces cerevisiae | |
pyridine-2,3-dicarboxylate | - |
Saccharomyces cerevisiae | |
Pyridine-2,4-dicarboxylate | - |
Saccharomyces cerevisiae | |
Pyridine-2,5-dicarboxylate | - |
Saccharomyces cerevisiae | |
pyridine-2,6-dicarboxylate | - |
Saccharomyces cerevisiae | |
pyridine-2-carboxylate | - |
Saccharomyces cerevisiae | |
succinyl phosphonate | - |
Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | bound in the active site | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | mechanism: 2-oxoglutarate first binds to the active site zinc via its alpha-carboxylate and 2-oxo groups, followed by acetyl-CoA. A general base then accepts a proton from the methyl of acetyl-CoA, and a general acid protonates the carbonyl of 2-oxoglutarate in the formation of homocitryl-CoA. The general acid then acts as a base in deprotonating Zn-OH2 in the hydrolysis of homocitryl-CoA to give homocitrate and CoA | Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
glyoxylate | pH 7.2 | Saccharomyces cerevisiae | |
0.43 | - |
pyridine-2-carboxylate | pH 7.2 | Saccharomyces cerevisiae | |
0.6 | - |
Pyridine-2,4-dicarboxylate | pH 7.2 | Saccharomyces cerevisiae | |
0.7 | - |
pyridine-2,6-dicarboxylate | pH 7.2 | Saccharomyces cerevisiae | |
1 | - |
oxalate | pH 7.2 | Saccharomyces cerevisiae | |
3 | - |
pyridine-2,3-dicarboxylate | pH 7.2 | Saccharomyces cerevisiae | |
4 | - |
oxaloacetate | pH 7.2 | Saccharomyces cerevisiae | |
7.7 | - |
oxalylglycine | pH 7.2 | Saccharomyces cerevisiae | |
10 | - |
2-Oxomalonate | pH 7.2 | Saccharomyces cerevisiae | |
14 | - |
Pyridine-2,5-dicarboxylate | pH 7.2 | Saccharomyces cerevisiae | |
26 | - |
2-oxoglutarate | pH 7.2 | Saccharomyces cerevisiae | |
26 | - |
Glutarate | pH 7.2 | Saccharomyces cerevisiae | |
46 | - |
succinyl phosphonate | pH 7.2 | Saccharomyces cerevisiae |