Protein Variants | Comment | Organism |
---|---|---|
D362A | acetyl-CoA binding site mutant, reduced turnover, increased Ki for oxaloacetate and 2-oxoglutarate | Escherichia coli |
F383A | acetyl-CoA binding site mutant, reduced turnover | Escherichia coli |
H229Q | active site mutant, reduced turnover, increased Ki for 2-oxoglutarate | Escherichia coli |
H264A | acetyl-CoA binding site mutant, reduced turnover, increased Ki for oxaloacetate and 2-oxoglutarate | Escherichia coli |
H305A | active site mutant, reduced turnover | Escherichia coli |
additional information | effect of active-site mutantions on substrate binding | Escherichia coli |
R314L | active site mutant, reduced turnover | Escherichia coli |
R387L | active site mutant, reduced turnover | Escherichia coli |
R407L | active site mutant, reduced turnover, increased Ki for oxaloacetate and 2-oxoglutarate | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | wild-type and mutants | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | mutants, with and without KCl, overview | Escherichia coli | |
0.026 | - |
oxaloacetate | wild-type | Escherichia coli | |
0.12 | - |
acetyl-CoA | wild-type | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
KCl | mutants, overview | Escherichia coli | |
KCl | 39fold activation at saturating concentration, wild-type | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + oxaloacetate + H2O | - |
Escherichia coli | citrate + CoA | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | mutants, overview | Escherichia coli | |
0.76 | - |
2-oxoglutarate | wild-type | Escherichia coli |