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Literature summary for 2.3.3.2 extracted from
- Properties of 2-decylcitrate synthase from Penicillium spiculisporum Lehman (1971), Eur. J. Biochem., 22, 104-114.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithio-bis-(2-nitrobenzoic acid) | - |
Talaromyces trachyspermus |  |
| acetyl-CoA | - |
Talaromyces trachyspermus | |
| CoASSCoA | - |
Talaromyces trachyspermus | |
| iodoacetamide | - |
Talaromyces trachyspermus | |
| lauroyl-CoA | strong substrate inhibition, does not follow Michaelis-Menten kinetics | Talaromyces trachyspermus | |
| N-ethylmaleimide | - |
Talaromyces trachyspermus | |
| NADH | at 5 mM, slight inhibition | Talaromyces trachyspermus | |
| p-chloromercuribenzoate | - |
Talaromyces trachyspermus | |
| palmitoyl-CoA | - |
Talaromyces trachyspermus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
lauroyl-CoA | - |
Talaromyces trachyspermus | |
| 0.03 | - |
11-formamidoundecanoyl-CoA | - |
Talaromyces trachyspermus | |
| 0.035 | - |
oxaloacetate | at 0.021 mM lauroyl-CoA | Talaromyces trachyspermus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
2 * 45000, SDS-PAGE | Talaromyces trachyspermus |
| 90000 | - |
gel filtration | Talaromyces trachyspermus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lauroyl-CoA + H2O + oxaloacetate | Talaromyces trachyspermus | - |
(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA | - |
? | |
| lauroyl-CoA + H2O + oxaloacetate | Talaromyces trachyspermus Lehman | - |
(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Talaromyces trachyspermus | - |
- |
- |
| Talaromyces trachyspermus Lehman | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Talaromyces trachyspermus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -18°C, 0.5 M (NH4)2SO4, 20% activity loss, 2 months | Talaromyces trachyspermus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11-formamidoundecanoyl-CoA + H2O + oxaloacetate | - |
Talaromyces trachyspermus | (2S,3S)-2-hydroxy-11-formamidotridecanoyl + CoA | - |
? | |
| 11-formamidoundecanoyl-CoA + H2O + oxaloacetate | - |
Talaromyces trachyspermus Lehman | (2S,3S)-2-hydroxy-11-formamidotridecanoyl + CoA | - |
? | |
| lauroyl-CoA + H2O + oxaloacetate | - |
Talaromyces trachyspermus | (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA | - |
? | |
| lauroyl-CoA + H2O + oxaloacetate | - |
Talaromyces trachyspermus Lehman | (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 45000, SDS-PAGE | Talaromyces trachyspermus |
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Release 2023.1 (January 2023)
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