Literature summary for 2.3.3.8 extracted from

Hatzivassiliou, G.; Zhao, F.; Bauer, D.E.; Andreadis, C.; Shaw, A.N.; Dhanak, D.; Hingorani, S.R.; Tuveson, D.A.; Thompson, C.B.
ATP citrate lyase inhibition can suppress tumor cell growth (2005), Cancer Cell, 8, 311-321.

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Application

Application	Comment	Organism
medicine	ATP citrate synthase inhibition by RNAi or the chemical SB-204990 limits in vitro proliferation and survival of tumor cells displaying aerobic glycolysis	Homo sapiens
medicine	ATP citrate synthase inhibition by RNAi or the chemical SB-204990 limits in vitro proliferation and survival of tumor cells displaying aerobic glycolysis. The same treatments also reduce in vivo tumor growth and induce differentiation	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
SB-204990	-	Homo sapiens
SB-204990	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
K-562 cell	-	Homo sapiens	-
PC-3 cell	-	Homo sapiens	-
SKOV-3 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)