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Literature summary for 2.3.3.8 extracted from

  • Chypre, M.; Zaidi, N.; Smans, K.
    ATP-citrate lyase: a mini-review (2012), Biochem. Biophys. Res. Commun., 422, 1-4.
    View publication on PubMed
Search for more literature for 2.3.3.8

Crystallization (Commentary)

Crystallization (Comment) Organism
in the presence of tartrate, ATP and magnesium ions Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(+)-2,2-difluorocitrate
-
 Homo sapiens
(+)-2,2-difluorocitrate
-
 Mus musculus
(-)-2,2-difluorocitrate
-
 Homo sapiens
(-)-2,2-difluorocitrate
-
 Mus musculus
(-)-Hydroxycitrate potent inhibitor Homo sapiens
(-)-Hydroxycitrate potent inhibitor Mus musculus
radicicol noncompetitive inhibitor Homo sapiens
radicicol noncompetitive inhibitor Mus musculus
SB-204990
-
 Homo sapiens
SB-204990
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
cytosol
-
 Homo sapiens 5829
-
endoplasmic reticulum
-
 Mus musculus 5783
-
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + citrate + CoA Mus musculus
-
 acetyl-CoA + oxaloacetate + ADP + phosphate
-
 ir
ATP + citrate + CoA Homo sapiens
-
 acetyl-CoA + oxaloacetate + ADP + phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of the enzyme at Thr446, Ser450 and Ser454 is enhanced by glucagon, insulin, vasopressin and transforming growth factor beta1 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain low expression Mus musculus
-
brain low expression Homo sapiens
-
colonic adenocarcinoma cell
-
 Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
heart low expression Mus musculus
-
heart low expression Homo sapiens
-
liver high expression Mus musculus
-
liver high expression Homo sapiens
-
MEF cell
-
 Mus musculus
-
muscle low expression Mus musculus
-
muscle low expression Homo sapiens
-
pro-B-lymphocyte
-
 Mus musculus
-
small intestine low expression Mus musculus
-
small intestine low expression Homo sapiens
-
white adipose tissue high expression Mus musculus
-
white adipose tissue high expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + citrate + CoA
-
 Mus musculus acetyl-CoA + oxaloacetate + ADP + phosphate
-
 ir
ATP + citrate + CoA
-
 Homo sapiens acetyl-CoA + oxaloacetate + ADP + phosphate
-
 ir

Subunits

Subunits Comment Organism
homotetramer
-
 Mus musculus
homotetramer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
ACLY
-
 Mus musculus
ACLY
-
 Homo sapiens
ATP-citrate lyase
-
 Mus musculus
ATP-citrate lyase
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus sterol regulatory element binding protein-1 up-regulates the enzyme at mRNA level via Akt signaling up
Homo sapiens sterol regulatory element binding protein-1 up-regulates the enzyme at mRNA level via Akt signaling up

General Information

General Information Comment Organism
malfunction overexpression of the enzyme is observed in nonalcoholic fatty liver disease. Increased enzyme activity is associated with hypocituria, nonalcoholic fatty liver disease, and tumor cell growth. Decreased enzyme activity is associated with type 2 diabetes. ACLY knockdown or inhibition leads to a decrease in glucose-induced insulin secretion Homo sapiens
metabolism the enzyme is involved in citrate metabolism Mus musculus
metabolism the enzyme is involved in citrate metabolism Homo sapiens
physiological function the enzyme is essentially required for embryonic development. Increased enzyme activity is found in the fetal development of the brain Mus musculus