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Literature summary for 2.3.3.8 extracted from

  • Lee, J.H.; Jang, H.; Lee, S.M.; Lee, J.E.; Choi, J.; Kim, T.W.; Cho, E.J.; Youn, H.D.
    ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway (2015), FEBS J., 282, 361-371.
    View publication on PubMed
Search for more literature for 2.3.3.8

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alpha cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate Homo sapiens
-
 ATP + citrate + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose bead chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
dermal fibroblast
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate
-
 Homo sapiens ATP + citrate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACLY
-
 Homo sapiens
ATP-citrate lyase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown triggers cellular senescence and activation of tumor suppressor p53 Homo sapiens
physiological function the enzyme regulates cellular senescence via an AMPK- and p53-dependent pathway Homo sapiens