Cloned (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
mixed alpha/beta structure | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Bromopyruvate | - |
Mycobacterium tuberculosis | |
glycolate | only at fairly high concentration | Mycobacterium tuberculosis | |
malate | 1.0 mM, 50% inhibition | Mycobacterium tuberculosis | |
additional information | 3-phosphoglycerate, 6-phosphogluconate, malonic acid; not: fructose 1,6-bisphosphate | Mycobacterium tuberculosis | |
oxalate | - |
Mycobacterium tuberculosis | |
phosphoenolpyruvate | - |
Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
acetyl-CoA | recombinant enzyme | Mycobacterium tuberculosis | |
0.057 | - |
glyoxylate | recombinant enzyme | Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | absolute requirement for divalent cation, maximal activity with 5 mM Mg2+ | Mycobacterium tuberculosis | |
Mn2+ | 40% of the activation with Mg2+ | Mycobacterium tuberculosis | |
additional information | Co2+, Fe2+, Ca2+, Ba2+, Ni2+, Cd2+, Zn2+, Cu2+, Hg2+ are not able to support the activity of enzyme | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Mycobacterium tuberculosis |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA | mechanism | Mycobacterium tuberculosis |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
6 | - |
recombinant enzyme | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glyoxylate + acetyl-CoA + H2O | structure of enzyme-substrate complex | Mycobacterium tuberculosis | (S)-malate + CoA | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
Bromopyruvate | - |
Mycobacterium tuberculosis | |
0.2 | - |
phosphoenolpyruvate | - |
Mycobacterium tuberculosis | |
0.4 | - |
oxalate | - |
Mycobacterium tuberculosis | |
0.9 | - |
glycolate | - |
Mycobacterium tuberculosis |