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Literature summary for 2.4.1.1 extracted from
- The inhibition of glycogen phosphorylase by uridine diphosphate glucose (1961), Biochem. Biophys. Res. Commun., 6, 310-313.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| UDP | at high glucose 1-phosphate concentration, glycogen synthesis, not phosphorolysis | Oryctolagus cuniculus |  |
| UDPglucose | competitive to glucose 1-phosphate, non-competitive to phosphate | Agrobacterium tumefaciens | |
| UDPglucose | competitive to glucose 1-phosphate, non-competitive to phosphate | Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Oryctolagus cuniculus | |
| 1.6 | - |
glucose 1-phosphate | - |
Agrobacterium tumefaciens | |
| 1.7 | - |
glucose 1-phosphate | phosphorylase a | Oryctolagus cuniculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agrobacterium tumefaciens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Agrobacterium tumefaciens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycogen + glucose 1-phosphate | - |
Oryctolagus cuniculus | glycogen + phosphate | - |
r | |
| glycogen + glucose 1-phosphate | - |
Agrobacterium tumefaciens | glycogen + phosphate | - |
r | |
| [(1->4)-alpha-D-glucosyl]n + phosphate | - |
Oryctolagus cuniculus | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r | |
| [(1->4)-alpha-D-glucosyl]n + phosphate | - |
Agrobacterium tumefaciens | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | requirement | Oryctolagus cuniculus | |
| pyridoxal 5'-phosphate | requirement | Agrobacterium tumefaciens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.67 | - |
UDPglucose | - |
Agrobacterium tumefaciens | |
| 0.92 | - |
UDPglucose | - |
Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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