Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.1 extracted from

  • Vereb, G.; Fodor, A.; Bot, G.
    Kinetic characterization of rabbit skeletal muscle phosphorylase ab hybrid (1987), Biochim. Biophys. Acta, 915, 19-27.
    View publication on PubMed
Search for more literature for 2.4.1.1

Activating Compound

Activating Compound Comment Organism Structure
5'-AMP activation Oryctolagus cuniculus
IMP 0.1 mM, half-maximal activation of phosphorylase ab Oryctolagus cuniculus
phosphate activation Oryctolagus cuniculus
Phosphorylase kinase activation Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
D-glucose 5 mM and 8.5 mM, 50% inhibition of phosphorylase ab at 8 mM and 16 mM glucose 1-phosphate, 23 mM and 40 mM, 50% inhibition of phosphorylase a Oryctolagus cuniculus
glucose 6-phosphate
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic data Oryctolagus cuniculus
3.56
-
 glucose 1-phosphate phosphorylase a Oryctolagus cuniculus
18
-
 glucose 1-phosphate phosphorylase ab Oryctolagus cuniculus
20
-
 glucose 1-phosphate phosphorylase ab Oryctolagus cuniculus
28
-
 phosphate phosphorylase ab Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification activation by phosphorylation Oryctolagus cuniculus

Purification (Commentary)

Purification (Comment) Organism
phosphorylase ab hybrid Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
muscle skeletal muscle Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycogen + glucose 1-phosphate
-
 Oryctolagus cuniculus glycogen + phosphate
-
 r
[(1->4)-alpha-D-glucosyl]n + phosphate
-
 Oryctolagus cuniculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5
-
 glucose 6-phosphate phosphorylase ab Oryctolagus cuniculus
4.5
-
 glucose phosphorylase ab and a Oryctolagus cuniculus