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Literature summary for 2.4.1.1 extracted from

  • Chrysina, E.D.; Kosmopoulou, M.N.; Kardakaris, R.; Bischler, N.; Leonidas, D.D.; Kannan, T.; Loganathan, D.; Oikonomakos, N.G.
    Binding of beta-D-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies (2005), Bioorg. Med. Chem., 13, 765-772.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme complexed with inhibitor beta-D-glucopyranosyl bismethoxyphosphoramidate by soaking of native enzyme crystals in 150 mM inhibitor 7.5 h prior to diffraction data collection, X-ray diffraction structure determination and analysis at 1.83 A resolution, modeling Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
beta-D-glucopyranosyl bismethoxyphosphoramidate weak competitive inhibitor, binds at the catalytic site and induces conformational changes in the vicinity of the site, inhibition mechanism, overview Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P00489
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-

Reaction

Reaction Comment Organism Reaction ID
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate catalytic site structure Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1,4-alpha-D-glucosyl)n + phosphate polysaccharide substrate is glycogen Oryctolagus cuniculus (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
r

Synonyms

Synonyms Comment Organism
glycogen phosphorylase b
-
Oryctolagus cuniculus
GP
-
Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at, synthesis reaction Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at, synthesis reaction Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.9
-
beta-D-glucopyranosyl bismethoxyphosphoramidate pH 6.8, 30°C, versus alpha-D-glucose 1-phosphate, synthesis reaction Oryctolagus cuniculus