Literature summary for 2.4.1.102 extracted from

Ben-Mahmud, B.M.; Chan, W.H.; Abdulahad, R.M.; Datti, A.; Orlacchio, A.; Kohner, E.M.; Chibber, R.
Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy (2006), Diabetologia, 49, 2185-2191.

Search for more literature for 2.4.1.102

Application

Application	Comment	Organism
medicine	the results reveal a rationale towards a specific treatment of diabetic retinopathy, based on the inhibition of core 2 GlcNAc-T activity and/or the blockage of cognate glycans	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	glucose levels, plasma TNF-alpha nd core 2 GlcNAc-T activity are functionally linked with dabetic retinopathy	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation increases activity	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	glucose levels, plasma TNF-alpha nd core 2 GlcNAc-T activity are functionally linked with dabetic retinopathy	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
core 2 beta-1,6-N-acetylglucosaminyltransferase	-	Homo sapiens
core 2 GlcNAc-T	-	Homo sapiens

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Release 2023.1 (January 2023)