Literature summary for 2.4.1.102 extracted from

Sato, T.; Yoneyama, T.; Tobisawa, Y.; Hatakeyama, S.; Yamamoto, H.; Kojima, Y.; Mikami, J.; Mori, K.; Hashimoto, Y.; Koie, T.; Ohyama, C.
Core 2 beta-1, 6-N-acetylglucosaminyltransferase-1 expression in prostate biopsy specimen is an indicator of prostate cancer aggressiveness (2016), Biochem. Biophys. Res. Commun., 470, 150-156.

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Application

Application	Comment	Organism
diagnostics	GCNT1 expression in prostate biopsy specimen is a significant and independent predictor of recurrence after radical prostatectomy, which can be used in pre-treatment decision making for the patient	Homo sapiens
medicine	GCNT1 expression in prostate biopsy specimen is a significant and independent predictor of recurrence after radical prostatectomy, which can be used in pre-treatment decision making for the patient	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q02742	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DU-145 cell	-	Homo sapiens	-
LNCaP cell	-	Homo sapiens	-
prostate cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
core 2 beta-1, 6-N-acetylglucosaminyltransferase-1	-	Homo sapiens
GCNT1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	GCNT1-overexpressing cells produce a significantly larger amount of growth factors when cocultured with prostate stromal cells compared with GCNT1-knocked down cells and form larger tumors	Homo sapiens
metabolism	the enzyme is involved in the biosynthetic pathways for core2 O-glycans, overview. The core1 structure is converted to branched core2 structure (Core2) by GCNT1, GCNT3, and GCNT4	Homo sapiens
physiological function	core 2 beta-1, 6-N-acetylglucosaminyltransferase-1 (GCNT1) is a key enzyme that forms core 2 branched O-glycans. GCNT1 expression is correlated with D'Amico's recurrence risk classification. GCNT1-negative tumors are associated with significantly better prostate-specific antigen (PSA)-free survival compared with GCNT1-positive tumors. GCNT1 expression status is an independent risk factor for PSA recurrence after radical prostatectomy	Homo sapiens

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Release 2023.1 (January 2023)