Literature summary for 2.4.1.102 extracted from

Miyamoto, T.; Suzuki, A.; Asaka, R.; Ishikawa, K.; Yamada, Y.; Kobara, H.; Nakayama, J.; Shiozawa, T.
Immunohistochemical expression of core 2 beta1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor (2013), Histopathology, 62, 986-993.

Search for more literature for 2.4.1.102

Application

Application	Comment	Organism
diagnostics	C2GnT1 might become a prognostic factor for endometrial carcinoma. Patients with C2GnT1 overexpression show significantly shorter survival, multivariable analysis also indicate that 2GnT1 overexpression is an independent prognostic factor	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene GCNT2, recombinant expression in COS7 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene GCNT2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endometrial carcinoma cell	expression of C2GnT1 in 84 cases of endometrioid-type endometrial carcinoma, 15 cases of endometrial hyperplasia, and 30 normal endometria, immunohistochemic analysis, overview. C2GnT1 is strongly expressed at the invasive tumour front in several cases	Homo sapiens	-
additional information	topologically, C2GnT1 is strongly expressed at sites of deep myometrial invasion	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
C2GnT1	-	Homo sapiens
core 2 beta1,6-N-acetylglucosaminyl transferase 1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	C2GnT1 synthesizes the core 2 branching structure by catalysing the transfer of GlcNAc from UDP-GlcNAc with a beta1,6-linkage to GalNAc of the core 1 chain. On this core 2 branch, several tumour-associated carbohydrate structures, such as sLex and sLea, are synthesized. The enzyme may be associated with the biological aggressiveness of tumour cells, relationship between the expression of C2GnT1 and clinicopathological parameters of patients with endometrial carcinoma, overview	Homo sapiens

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Release 2023.1 (January 2023)