Literature summary for 2.4.1.102 extracted from

Lete, C.; Markine-Goriaynoff, N.; Machiels, B.; Pang, P.C.; Xiao, X.; Canis, K.; Suzuki, M.; Fukuda, M.; Dell, A.; Haslam, S.M.; Vanderplasschen, A.; Gillet, L.
Bovine herpesvirus 4 modulates its beta-1,6-N-acetylglucosaminyltransferase activity through alternative splicing (2015), J. Virol., 90, 2039-2051.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene Bo17, DNA and amino acid sequence determination and analysis, two different mRNAs are encoded by the Bo17 gene of all available BoHV-4 strains. While the first one corresponds to the entire coding sequence of the Bo17 gene, the second results from the splicing of a 138-bp intron encoding critical residues of the enzyme. The first one is enzymatically active, the second is inactive and results from the alternative splicing of the region encoding the catalytic site of the enzyme, enzyme activities in infected cells, overview	Bovine gammaherpesvirus 4

Cloned (Comment)

Organism

gene Bo17, DNA and amino acid sequence determination and analysis, two different mRNAs are encoded by the Bo17 gene of all available BoHV-4 strains. While the first one corresponds to the entire coding sequence of the Bo17 gene, the second results from the splicing of a 138-bp intron encoding critical residues of the enzyme. The first one is enzymatically active, the second is inactive and results from the alternative splicing of the region encoding the catalytic site of the enzyme, enzyme activities in infected cells, overview

Bovine gammaherpesvirus 4

Inhibitors

Inhibitors	Comment	Organism	Structure
jacalin	core 1 O-glycan-specific lectin from Artocarpus integrifolia, differing sensitivity of different BoHV-4 mutants to jacalin-mediated neutralization, overview	Bovine gammaherpesvirus 4
additional information	Bo17 splicing reduces BoHV-4 glycosylation	Bovine gammaherpesvirus 4

Organism

Organism	UniProt	Comment	Textmining
Bovine gammaherpesvirus 4	Q9IZK2	BoHV-4, gene Bo17	-
Bovine gammaherpesvirus 4 V. test	Q9IZK2	BoHV-4, gene Bo17	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	infection of MDBK cells with strain BoHV-4 V.test	Bovine gammaherpesvirus 4	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-N-acetyl-D-glucosamine + glycoprotein gp180	-	Bovine gammaherpesvirus 4	UDP + N-acetyl-beta-D-glucosaminyl-glycoprotein gp180	-	?
UDP-N-acetyl-D-glucosamine + glycoprotein gp180	-	Bovine gammaherpesvirus 4 V. test	UDP + N-acetyl-beta-D-glucosaminyl-glycoprotein gp180	-	?

Synonyms

Synonyms	Comment	Organism
beta-1,6-N-acetylglucosaminyltransferase	-	Bovine gammaherpesvirus 4
c2GnT-M	-	Bovine gammaherpesvirus 4
core 2 protein beta-1,6-N-acetylglucosaminyltransferase-mucin type	-	Bovine gammaherpesvirus 4

General Information

General Information	Comment	Organism
evolution	in contrast to cellular homologues, this virus has evolved to alternatively express two proteins from gene Bo17	Bovine gammaherpesvirus 4
malfunction	a Bo17 knockout strain does not display any growth deficit in vitro. But sole expression of either of the two Bo17-encoded proteins could influence BoHV-4 growth	Bovine gammaherpesvirus 4
additional information	the two isoforms of Bo17 are expressed in BoHV-4 infected cells, but enzymatic assays revealed that the spliced form is not active	Bovine gammaherpesvirus 4
physiological function	Bovine herpesvirus 4 modulates its beta-1,6-N-acetylglucosaminyltransferase activity through alternative splicing. The enzyme is a homologue of the cellular core 2 protein beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M), which is a key player for the synthesis of complex O-glycans	Bovine gammaherpesvirus 4