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Literature summary for 2.4.1.109 extracted from

  • Lommel, M.; Schott, A.; Jank, T.; Hofmann, V.; Strahl, S.
    A conserved acidic motif is crucial for enzymatic activity of protein O-mannosyltransferases (2011), J. Biol. Chem., 286, 39768-39775.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.109

Protein Variants

Protein Variants Comment Organism
D77A the PMT1 mutant shows 71.95% activity compared to the wild type enzyme Homo sapiens
D77A/E78A the PMT1 mutant shows 0.19% activity compared to the wild type enzyme Homo sapiens
D77A/E78A the PMT1 mutant shows 3.59% activity compared to the wild type enzyme Homo sapiens
D77A/E78A/D92A/E93A the PMT1/PMT2 mutant shows 0.24% activity compared to the wild type enzyme Homo sapiens
D80A the PMT4 mutant shows 3.21% activity compared to the wild type enzyme Homo sapiens
D80E the PMT4 mutant shows 52.98% activity compared to the wild type enzyme Homo sapiens
D80E/E81D the PMT4 mutant shows 116.54% activity compared to the wild type enzyme Homo sapiens
D92A/E93A the PMT2 mutant shows 3.63% activity compared to the wild type enzyme Homo sapiens
D96A the PMT1 mutant shows 63.21% activity compared to the wild type enzyme Homo sapiens
E78A the PMT1 mutant shows 46.68% activity compared to the wild type enzyme Homo sapiens
E81A the PMT4 mutant shows 1.43% activity compared to the wild type enzyme Homo sapiens
E81D the PMT4 mutant shows 46.59% activity compared to the wild type enzyme Homo sapiens
F76A the PMT1 mutant shows 78.79% activity compared to the wild type enzyme Homo sapiens
F81A the PMT1 mutant shows 71.71% activity compared to the wild type enzyme Homo sapiens
H80A the PMT1 mutant shows 83.03% activity compared to the wild type enzyme Homo sapiens
H98A the PMT1 mutant shows 62.77% activity compared to the wild type enzyme Homo sapiens
P100A the PMT1 mutant shows 59.67% activity compared to the wild type enzyme Homo sapiens
P99A the PMT1 mutant shows 61.77% activity compared to the wild type enzyme Homo sapiens
V97A the PMT1 mutant shows 80.23% activity compared to the wild type enzyme Homo sapiens
Y88A the PMT1 mutant shows 73.79% activity compared to the wild type enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
membrane a membrane protein Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
88000
-
 x * 88000, Pmt2p Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dolichyl phosphate D-mannose + N-acetyl-SSSSS worst substrate Homo sapiens dolichyl phosphate + O-D-mannosyl-N-acetyl-SSSSS
-
 ?
dolichyl phosphate D-mannose + N-acetyl-YASAV
-
 Homo sapiens dolichyl phosphate + O-D-mannosyl-N-acetyl-YASAV
-
 ?
dolichyl phosphate D-mannose + N-acetyl-YATAV best substrate Homo sapiens dolichyl phosphate + O-D-mannosyl-N-acetyl-YATAV
-
 ?
dolichyl phosphate D-mannose + N-acetyl-YATAVK-biotin N-acetyl-YATAVK-biotin preferentially reacts with isoform Pmt1p Homo sapiens dolichyl phosphate + O-D-mannosyl-N-acetyl-YATAVK-biotin
-
 ?

Subunits

Subunits Comment Organism
? x * 88000, Pmt2p Homo sapiens

Synonyms

Synonyms Comment Organism
dolichyl-phosphate-mannose-protein mannosyltransferase 1
-
 Homo sapiens
PMT
-
 Homo sapiens
Pmt1p-Pmt2p
-
 Homo sapiens
Pmt4p
-
 Homo sapiens