Literature summary for 2.4.1.12 extracted from

Taylor, N.G.
Identification of cellulose synthase AtCesA7 (IRX3) in vivo phosphorylation sites - a potential role in regulating protein degradation (2007), Plant Mol. Biol., 64, 161-171.

Search for more literature for 2.4.1.12

General Stability

General Stability	Organism
full length endogenous CesA7 is degraded via a proteasome dependant pathway in whole plant extracts. Phosphorylation of the catalytic subunits may target them for degradation via a proteasome dependant pathway. This is a possible mechanism by which plants regulate the relative levels of the three proteins whose specific interaction are required to form an active cellulose synthase complex	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Arabidopsis thaliana	phosphorylation and subsequent degradation via a proteasome dependant pathway is a possible mechanism by which plants regulate the relative levels of the different cellulose synthase catalytic subunits that are essential for cellulose synthesis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q9SWW6	cellulose synthase A catalytic subunit 7 [UDP-forming]	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	AtCesA7 is phosphorylated in vivo at two serine residues in a region of hyper-variability between the cellulose synthase catalytic subunits. Full length endogenous CesA7 is degraded via a proteasome dependant pathway in whole plant extracts. Phosphorylation of the catalytic subunits may target them for degradation via a proteasome dependant pathway. This is a possible mechanism by which plants regulate the relative levels of the three proteins whose specific interaction are required to form an active cellulose synthase complex	Arabidopsis thaliana

Source Tissue

Source Tissue	Comment	Organism	Textmining
stem	-	Arabidopsis thaliana	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	phosphorylation and subsequent degradation via a proteasome dependant pathway is a possible mechanism by which plants regulate the relative levels of the different cellulose synthase catalytic subunits that are essential for cellulose synthesis	Arabidopsis thaliana	?	-	?

Synonyms

Synonyms	Comment	Organism
AtCesA7	-	Arabidopsis thaliana
IRX3	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)