Cloned (Comment) | Organism |
---|---|
cloning of the C-terminal catalytic domain (amino acids 44-388) of C2GalTA into the vector pMT(1B) and transfected into S2 cells | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Drosophila melanogaster | enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q7JRF9 | isoform A | - |
Drosophila melanogaster | Q7K237 | - |
- |
Drosophila melanogaster | Q7K509 | isoform B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amnioserosa | in embryo | Drosophila melanogaster | - |
central nervous system | in embryo | Drosophila melanogaster | - |
embryo | - |
Drosophila melanogaster | - |
gut | in larvae | Drosophila melanogaster | - |
imago | in larvae | Drosophila melanogaster | - |
larva | - |
Drosophila melanogaster | - |
nervous system | in larvae | Drosophila melanogaster | - |
salivary gland | - |
Drosophila melanogaster | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
C1GalTA exhibits high activity on Tn and glycopeptide substrates, although it also exhibits weaker activity on glycolipids | Drosophila melanogaster |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage | Drosophila melanogaster | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C1GalTA | - |
Drosophila melanogaster |
core 1 galactosyltransferase A | - |
Drosophila melanogaster |
core 1 GalT | - |
Drosophila melanogaster |
galactosyltransferase | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | C1GalTA null mutant is lethal, mutant animals exhibit a striking morphogenetic defect in which the ventral nerve cord is greatly elongated and the brain hemispheres are misshapen | Drosophila melanogaster |
physiological function | C1GalTA is required for nervous system morphogenesis, C1GalTA is required for laminin O-glycosylation | Drosophila melanogaster |