Crystallization (Comment) | Organism |
---|---|
complex of neryl-moenomycin A bound to the peptidoglycan glycosyltransferase domain of PBP1A | Aquifex aeolicus |
Protein Variants | Comment | Organism |
---|---|---|
E83A | mutant with undetectable activity | Aquifex aeolicus |
K124A | mutant shows 5fold reduced activity compared to the wild type enzyme | Aquifex aeolicus |
K137A | mutant with undetectable activity | Aquifex aeolicus |
Q121A | mutant with undetectable activity | Aquifex aeolicus |
R132A | mutant with barely detectable activity (about 3% of wild type) | Aquifex aeolicus |
S116A | mutant shows 10fold reduced activity compared to the wild type enzyme | Aquifex aeolicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
moenomycin A | active site inhibitor | Aquifex aeolicus | |
neryl-moenomycin A | active site inhibitor | Aquifex aeolicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aquifex aeolicus | O66874 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Aquifex aeolicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | - |
Aquifex aeolicus | [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PBP1a | - |
Aquifex aeolicus |
PGT | - |
Aquifex aeolicus |