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Literature summary for 2.4.1.133 extracted from

  • Yang, H.; Yan, M.; Cheng, C.; Jiang, J.; Zhang, L.; Liu, J.; Zhou, Z.; Shen, A.
    Expression of beta-1,4-galactosyltransferase I in rat Schwann cells (2009), J. Cell. Biochem., 108, 75-86.
    View publication on PubMed
Search for more literature for 2.4.1.133

Inhibitors

Inhibitors Comment Organism Structure
1,4-diamino-2,3-dicyano-1,4-bis-(2-aminophenylthio)butadiene 0-10 microM of specific inhibitor U0126 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide Rattus norvegicus
4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol 10-30 microM of specific inhibitor SB202190 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide Rattus norvegicus
pyrazolanthrone 10-50 microM of specific inhibitor SP600125 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + O-beta-D-xylosylprotein Rattus norvegicus
-
 UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RSC96 cell
-
 Rattus norvegicus
-
Schwann cell
-
 Rattus norvegicus
-
sciatic nerve
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + O-beta-D-xylosylprotein
-
 Rattus norvegicus UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
 ?

Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase I
-
 Rattus norvegicus
beta-1,4-GalT
-
 Rattus norvegicus
beta-1,4-GalT I
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the beta-1,4-GalT I mRNA reaches peaks at 2 weeks after sciatic nerve crush and 3 days after sciatic nerve transection in a dose-dependent manner, in inflammation, lipopolysaccharide administration affects beta-1,4-GalT I mRNA expression in sciatic nerve in a time- and dose-dependent manner, and beta-1,4-GalT I mRNA is expressed mainly in Schwann cells up

General Information

General Information Comment Organism
physiological function beta-1,4-GalT I might play important roles in Schwann cells during the regeneration and degeneration of the injured sciatic nerve, enzyme plays in important role in Schwann cells in vivo and vitro during pathology, beta-1,4-GalT can catalyze the galactose from UDP-galactose to the terminal N-acetylglucosamine residues on elongating oligosaccharide chains, which are suggested to be involved in various cellular functions including cell-cell and cell-matrix interactions during embryogenesis Rattus norvegicus