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Literature summary for 2.4.1.133 extracted from

  • Niu, S.; Fei, M.; Cheng, C.; Yan, M.; Gao, S.; Chen, M.; Wang, H.; Li, X.; Yu, X.; Qian, J.; Qin, J.; Zhao, J.; Gu, J.; Shen, A.
    Altered beta-1,4-galactosyltransferase I expression during early inflammation after spinal cord contusion injury (2008), J. Chem. Neuroanat., 35, 245-256.
    View publication on PubMed
Search for more literature for 2.4.1.133

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Rattus norvegicus 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + O-beta-D-xylosylprotein Rattus norvegicus
-
 UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rat
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte in the lesion site after spinal cord injury Rattus norvegicus
-
inflammatory cell
-
 Rattus norvegicus
-
macrophage in the lesion site after spinal cord injury Rattus norvegicus
-
microglia OX-42-positive microglia in the lesion site after spinal cord injury Rattus norvegicus
-
neutrophil in the lesion site after spinal cord injury Rattus norvegicus
-
oligodendrocyte in the lesion site after spinal cord injury Rattus norvegicus
-
spinal cord in the lesion site after spinal cord injury Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + O-beta-D-xylosylprotein
-
 Rattus norvegicus UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
 ?

Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase I
-
 Rattus norvegicus
beta-1,4-GalT-I
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus in injured spinal cords, enzyme is significantly increased after 8 h, beta-1,4-GalT-I mRNA reaches the peak at 1 day after spinal cord contusion, then gradually reduced from day 5 to day 7, recovers to the baseline level at 14 day up

General Information

General Information Comment Organism
physiological function beta-1,4-galactosyltransferase I is a key inflammatory mediator that plays a critical role in the initiation and maintenance of inflammatory reaction in diseases, beta-1,4-GalT-I is associated with E-selectin during the pathological process of secondary response after Spinal cord injury Rattus norvegicus