Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | enzyme catalyzes the transfer of galactose from the sugar nucleotide donor uridine diphosphate galactose to glycoside residues with a terminal N-acetylglucosamine moiety | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
microglia | - |
Rattus norvegicus | - |
primary cell line | mixed neuron-glial cultures prepared from the brains of embryonic days 16-17 rats | Rattus norvegicus | - |
ventral midbrain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme catalyzes the transfer of galactose from the sugar nucleotide donor uridine diphosphate galactose to glycoside residues with a terminal N-acetylglucosamine moiety | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-1,4-galactosyltransferase-I | - |
Rattus norvegicus |
beta-1,4-GalT-I | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | beta-1,4-GalT-I is strongly induced in the ventral midbrain by intranigral injection of lipopolysaccharide, significant increase in beta-1,4-GalT-I mRNA at 8 h after focal injection of lipopolysaccharide, and lastes to 18 h, then decreases gradually | up |
General Information | Comment | Organism |
---|---|---|
malfunction | an antibody against beta-1,4-GalT-I attenuates both lipopolysaccharide-induced microglial activation and phagocytosis | Rattus norvegicus |
physiological function | beta-1,4-GalT-I may play an important role in regulating immune cell migration into the inflammatory site and mediating microgliosis | Rattus norvegicus |