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Literature summary for 2.4.1.141 extracted from
- Regulation of the biosynthesis of N-acetylglucosaminylpyrophosphoryldolichol, feedback and product inhibition (1999), J. Biol. Chem., 274, 34072-34082.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| mannosyl-phosphodolichol | - |
Gallus gallus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diphosphodolichyl-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine | exogenously added, extensive inhibition in absence and presence of +mannosyl-phosphodolichol and showdomycin | Gallus gallus | |
| N-acetyl-D-glucosaminyl-diphosphodolichol | exogenously added, in presence of mannosyl-phosphodolichol | Gallus gallus | |
| Showdomycin | complete inhibition | Gallus gallus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Gallus gallus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
15-16 days old | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retina | - |
Gallus gallus | - |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Gallus gallus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0028 | - |
diphosphodolichyl-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine | - |
Gallus gallus | |
| 0.0044 | - |
N-acetyl-D-glucosaminyl-diphosphodolichol | - |
Gallus gallus | |
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