Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.142 extracted from

  • Kobayashi, M.; Jitoku, D.; Iwayama, Y.; Yamamoto, N.; Toyota, T.; Suzuki, K.; Kikuchi, M.; Hashimoto, T.; Kanahara, N.; Kurumaji, A.; Yoshikawa, T.; Nishikawa, T.
    Association studies of WD repeat domain 3 and chitobiosyldiphosphodolichol beta-mannosyltransferase genes with schizophrenia in a Japanese population (2018), PLoS ONE, 13, e0190991 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.142

Application

Application Comment Organism
pharmacology the WD repeat domain 3 (WDR3) and chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) genes are target candidates for schizophrenia-related molecules, whose mRNAs are upregulated in the adult (postnatal week seven), but not in the infant (postnatal week one) rats by an indirect dopamine agonist, and phencyclidine, an antagonist of the NMDA receptor Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
gene ALG1, located on chromosome 16p13.3, genomic structure, genotyping. Gene-gene interaction analysis of genes ALG1 and WDR3 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genotyping 10 single nucleotide polymorphisms from gene ALG1 are identified using the Japanese case-control sample (1808 schizophrenics and 2170 matched controls). Genotype-phenotype correlation analysis in schizophrenia patients, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol Homo sapiens
-
 GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol Rattus norvegicus
-
 GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BT22
-
-
Rattus norvegicus D4A5S6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 Homo sapiens GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 Rattus norvegicus GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?

Synonyms

Synonyms Comment Organism
ALG1
-
 Homo sapiens
ALG1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) mRNAs are upregulated greater in the adult (postnatal days 50) than in the infant (postnatal days 8) rats by schizophrenomimetics, methamphetamine and phencyclidine up

General Information

General Information Comment Organism
physiological function ALG1 is presumed to be involved in the regulation of the protein N-glycosylation. Genetic association of WDR3 and ALG1 in schizophrenia Rattus norvegicus
physiological function ALG1 is presumed to be involved in the regulation of the protein N-glycosylation. Genetic association of WDR3 and ALG1 in schizophrenia. The WDR3 gene may likely be a sensitive factor in female patients with schizophrenia Homo sapiens