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Literature summary for 2.4.1.143 extracted from

  • Geisler, C.; Jarvis, D.L.
    Substrate specificities and intracellular distributions of three N-glycan processing enzymes functioning at a key branch point in the insect N-glycosylation pathway (2012), J. Biol. Chem., 287, 7084-7097.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.143

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition in the presence of EDTA Spodoptera frugiperda

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Spodoptera frugiperda 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required for activity Spodoptera frugiperda

Organism

Organism UniProt Comment Textmining
Spodoptera frugiperda
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme cannot use Man3GlcNAc2 and Manalpha(1->6)[Manbeta(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAcbeta-2-pyridyl-aminoside as substrate Spodoptera frugiperda ?
-
 ?
UDP-N-acetyl-D-glucosamine + Manalpha(1->6)[GlcNAcbeta(1->2)-Manbeta(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAcbeta-2-pyridyl-aminoside the enzyme can transfer a second N-acetylglucosamine residue to the product of the first transferase reaction but in an extremely slow reaction that is unlikely to be biologically relevant Spodoptera frugiperda ?
-
 ?

Synonyms

Synonyms Comment Organism
GnT-II
-
 Spodoptera frugiperda
N-acetylglucosaminyltransferase II
-
 Spodoptera frugiperda

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
-
 Spodoptera frugiperda

pH Range

pH Minimum pH Maximum Comment Organism
6.7 8.1 the enzyme has an optimum pH of 6.7, with a broad shoulder of high activity from pH 7.1 to 8.1 Spodoptera frugiperda

General Information

General Information Comment Organism
metabolism the enzyme functions at the N-glycan processing branch point and is one of the major factors determining the net outcome of the insect cell N-glycosylation pathway Spodoptera frugiperda