Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-435 cell | - |
Homo sapiens | - |
additional information | MCF-7/AZ cell | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GnT-III | - |
Homo sapiens |
MGAT3 | - |
Homo sapiens |
N-acetylglucosaminyltransferase III | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | GnT-III knockdown in MCF-7/AZ cells through siRNA | down |
Homo sapiens | knockdown of GnT-III, de-localization of E-cadherin and cytoplasmic accumulation, modification of N-glycosylation in E-cadherin | down |
Homo sapiens | increase of enzyme expression by wild-type E-cadherin | up |
Homo sapiens | wild-type E-cadherin regulates MGAT3 gene transcription resulting in increased GnT-III expression. GnT-III mRNA transcription levels in MDA-MB-435 cells transfected with E-cadherin wild-type are ca. 2fold higher than those in MDA-MB-435 mock cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of GnT-III by siRNA causes no alteration in expression levels of E-cadherin mRNA and protein, but induces alterations on E-cadherin cellular localization in MCF-7/AZ cells. GnT-III knockdown cells reveal a membrane de-localization of E-cadherin leading to its cytoplasmic accumulation and cause modifications of E-cadherin N-glycans catalyzed by GnT-III and GnT-V | Homo sapiens |
physiological function | metastasis suppressor | Homo sapiens |