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Literature summary for 2.4.1.145 extracted from

  • Takamatsu, S.; Antonopoulos, A.; Ohtsubo, K.; Ditto, D.; Chiba, Y.; Le, D.T.; Morris, H.R.; Haslam, S.M.; Dell, A.; Marth, J.D.; Taniguchi, N.
    Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice (2010), Glycobiology, 20, 485-497.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.145

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Mus musculus
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bone marrow
-
 Mus musculus
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brain
-
 Mus musculus
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colon
-
 Mus musculus
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heart
-
 Mus musculus
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kidney
-
 Mus musculus
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liver
-
 Mus musculus
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lung
-
 Mus musculus
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lymph node
-
 Mus musculus
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additional information in wild type mice, GnT-IVa expression is restricted to gastrointestinal tissues, whereas GnT-IVb is broadly expressed among organs Mus musculus
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muscle
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 Mus musculus
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ovary
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 Mus musculus
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pancreas
-
 Mus musculus
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small intestine
-
 Mus musculus
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spleen
-
 Mus musculus
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stomach
-
 Mus musculus
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testis
-
 Mus musculus
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thymus
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 Mus musculus
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uterus
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine isozyme GnT-IVb has about 30% activity of isozyme GnT-IVa Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
GnT-IVa isozyme Mus musculus
GnT-IVb isozyme Mus musculus
N-acetylglucosaminyltransferase-IVa isozyme Mus musculus
N-acetylglucosaminyltransferase-IVb isozyme Mus musculus

General Information

General Information Comment Organism
malfunction isozyme GnT-IVb deficiency shows mild phenotypic alterations in hematopoietic cell populations and hemostasis, GnT-IVa/-IVb double deficiency completely abolishes GnT-IV activity that results in the disappearance of the GlcNAcbeta1-4 branch on the Manalpha1-3 arm Mus musculus