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Literature summary for 2.4.1.145 extracted from

  • Ohtsubo, K.
    Biological significance of N-acetylglucosaminyltransferase-IV-mediated protein glycosylation on the homeostasis of cellular physiological functions (2011), Trends Glycosci. Glycotechnol., 23, 103-105.
No PubMed abstract available
Search for more literature for 2.4.1.145

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
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Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
choriocarcinoma cell
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 Homo sapiens
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choriocarcinoma cell
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 Bos taurus
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gastrointestinal tract isoform GnT-IVa is highly restricted in gastrointestinal organs and peripheral blood leukocytes Bos taurus
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leukocyte isoform GnT-IVa is highly restricted in gastrointestinal organs and peripheral blood leukocytes Bos taurus
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additional information isoform GnT-IVb is ubiquitously and constitutively expressed among tissues Homo sapiens
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peripheral blood
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 Bos taurus
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Synonyms

Synonyms Comment Organism
GnT-IVa iozyme Bos taurus
GnT-IVb iozyme Homo sapiens
Mgat4a
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 Bos taurus
Mgat4b
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 Homo sapiens
N-acetylglucosaminyltransferase-IV
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 Homo sapiens
N-acetylglucosaminyltransferase-IV
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 Bos taurus

Expression

Organism Comment Expression
Bos taurus Mgat4a expression levels are significantly reduced in the pancreatic beta cells of type 2 diabetes patients down
Bos taurus Mgat4a expression is induced under hypoxic conditions. Isoform GnT-IVa expression is aberrantly up-regulated in some type of tumor cells up

General Information

General Information Comment Organism
metabolism N-acetylglucosaminyltransferase-IV synthesizes the GlcNAcbeta(1-4) branch structure on the Manalpha(1-3) arm of N-glycan core, and is essential for the production of multiantennary N-glycans cooperatively with N-acetylglucosaminyltransferase-V Homo sapiens
metabolism N-acetylglucosaminyltransferase-IV synthesizes the GlcNAcbeta(1-4) branch structure on the Manalpha(1-3) arm of N-glycan core, and is essential for the production of multiantennary N-glycans cooperatively with N-acetylglucosaminyltransferase-V Bos taurus