Literature summary for 2.4.1.146 extracted from

Liu, J.; Jin, C.; Cherian, R.M.; Karlsson, N.G.; Holgersson, J.
O-glycan repertoires on a mucin-type reporter protein expressed in CHO cell pools transiently transfected with O-glycan core enzyme cDNAs (2015), J. Biotechnol., 199, 77-89.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene B3GNT3, recombinant expression in CHO-K1 cells. Glycosylation-related genes in CHO-K1 cells are present, but strictly suppressed and regulated. CHO cells are transiently co-transfected with plasmids encoding extended C1 beta3GnT3, C2 beta6GnT1, or C3 beta3GnT6 with or without ST6Gal I or CHST4, respectively, and resulting O-glycan and core chain spectrum, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y2A9	gene B3GNT3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal adenocarcinoma cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
beta1,3-N-acetylglucosaminyltransferase 3	-	Homo sapiens
core 1 extension enzyme	-	Homo sapiens
extended C1 beta3GnT3	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	O-glycan biosynthesis pathways and proposed O-glycan structures of selected glycosyltransferases, overview. Core 1 dominates the O-glycan repertoire. Core 1 can be further elongated by extended C1 beta3GnT3 enzyme to form extended core 1 structure, or be modified by C2 beta6GnT1 enzyme, EC 2.4.1.102, to form core 2 O-glycans. Regulation of O-glycan biosynthesis, overview. The extended C1 beta3GnT3 is competing withthe endogenous ST3Gal	Homo sapiens

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Release 2023.1 (January 2023)